I’ve been on methotrexate for about a year now and it has really eased my pain from the Psa. My skin is clearer now too and so far my liver is fine. No side effects to report either.

I’ve been taking methotrexate for 30 years. First orally then started injecting it once a week the last?10 years? I’ve never had any issues and get my bloodwork done often. I also get bloodwork done for other medications that I take like Cosentyx, Cymbalta, etc.
Of course, EVERYTHING I take seems to say a side effect might be hair loss HAHAHA‼️I already HAVE thin hair so although I’m not happy about that, whatever works, I guess.
UPDATE: my rheumatologist just had me stop methotrexate and start a daily pill called Lefludomide. It was to try because I have been using methotrexate for like 30 years.

Methotrexate was the only medication that worked for my psoriasis. I was on 8x2.5mg Methotrexate tablets once a week and a 5mg. Folic Acid tablets the other six days. Skin cleared after about three months. My skin stayed great the three or four years I was on it, then it was reduced gradually till I was on 4x2.5mg Methotrexate once a week and the 5mg. Folic Acid for six days, and my psoriasis came back, albeit not as bad as when I had started on it. I had to come off it because I have a history of fatty liver disease and the doctor was concerned the Methotrexate may affect my liver disease.

When my psoriasis came back I was out on a biologic Stelara injection every twelve weeks, which didn’t seem to do much even after 18 months. Now I am on Skyrizi for about a year, trying it every eight weeks since every twelve weeks didn’t seem to be working. Will have to wait a few months to see if this takes effect.

Update on Skyrizi: It has done nothing for me either, so I will be starting on something new - Cimzia - if I get approved for it. It seems there is no oral medication out there that won’t affect my liver, so I keep being switched from one biologic to another in the hope one of them will work! Too bad I cannot take Methotrexate, because that is the only thing that has worked for me in all these years I have lived with psoriasis.

Methotrexate has serious side affects, reacts with many other meds, and should not be taken by women over 75
I am switching Dermatologist bc he cannotwillnot/doesn’t care read my chart to see I have taken med that would severely react with methotrexate

It works well for me i take it by intervenies . It takes about 30 min and works for about 8 wks .then I go again.