Amgevita (adalimumab) 22 weeks of bliss, completely cleared my skin, my knees stopped hurting, it was brilliant. But my body adapted so they put me on Taltz. Amgevita is an antirheumatic, Taltz is an interleukin inhibitor. Taltz was 5 months of pure hell, I had to be sedated for the pain but the dermatologist refused to believe I was having an adverse reaction. so I went to Eli Lilly, the manufacturer and they said stop immediately. This enraged the dermatologist - a patient making a decision, she said no more biologics for you because you decided to stop taltz!! I went to a private dermatologist and they saw the reply from Eli Lilly and said I am allergic to interleukin inhibitors 7 to 11 (from memory). So I begged for Cimzia, another antirheumatic. Bliss! Knees are OK, skin is almost clear, walking is easier. No shoulder pain, it's easy to forget I even have PsA. But my body will eventually adapt and I will have to switch to another antirheumatic.
So, it depends on what type you are on, Taltz had me bedridden for two months, switching back to an antirheumatic fixed every problem Taltz had caused. I've been researching this since I was diagnosed a year ago, I always had it on my skin, but never had joint pain until Feb 2023.

The only thing that has seriously reduced my pain and inflammation is ketamine therapy (administer by a physician). So far, since Feb 29, 2024, I’ve lost 35 of the 70 pounds I gained as a result of the medications, illnesses, and allergic reactions, my pain is managed to a 2-4 most of the time, and I’m more me than I’ve been in years! My CRP was over 5x the maximum of inflammation that people are supposed to have for most of the last 5 years. My CRP was down to a little over 3x the maximum. It might not sound like much, but it has made a HUGE difference for me.

Of course, that difference is a mixed bag: 1) reduced weight is a plus, 2) reduced CRP is a plus, 3) still being waaay over the max isn’t good, (4) people see me more as I was and think, subconsciously, that I should be responding quick and smooth and that I should be headed back to practicing law. Not gonna happen! They don’t understand the major impact on cognitive function and multi-tasking. It makes me incapable of having a live stressful discussion and anyone arguing around me stresses me way out of sight and when I talk about it, most people simply don’t “get it.” Thats true for people who absolutely love me.

Actually, my mental state on some medications led my brother to think I’m an alcoholic and drug addict instead of simply being very sick! How wrong is THAT!?!?!?

Anyway, that’s all I have to add for now.

God bless you!

I am on enbrel now with methrotrexate folic acid . Doing good both psoriatic arthritis and psoriasis. My Reynard has been better too. I was on humira 10 years. Skin broke out. Tried talz,skirizi not good. Enbrel good for both my psorasis and PsA.

I’ve been on Humira, Embrel, Stelara, Cosentyx, something else and now Tremfya. Nothing helped me with the pain, yet Embrel, Humeria, and Tremfya each have helped me with my other symptoms.
Each person’s body is different and will respond differently to each medication.

I have been on Skyrizi, Cosentyx and Stelara. Those have helped with psoriasis but not for the psoriatic arthritis pain. Still waiting on the one