I take methotrexate, and 20 mg of leflunomide. Infliximab infusions every 8 weeks. Since I started on the 8 week routine, it seems to lose effectiveness around the 5th to 6th week. I am also hoping to discontinue the methotrexate. Does anyone have any thoughts on if it is better to increase frequency versus increase dosage of infliximab. I tolerate it well so far, but end up in some pain prior to the next dose. Thank you.