So, has the initial stinging, burning and itching from the Tacrolimus subsided? I find most all of the topicals start out this way, but I have noticed less irritation from DuoBrii. Call me 'crazy' but it often seems like the side effects stop after awhile, and then, as the skin improves some, it starts again -- maybe the new skin like the topical even less?
Something I find that helps is to soften my feet and hands in warm water, then pat dry. I apply a lotion called Sarna -- most drugstores have an in-house version -- which suppresses the itch/burn. Let it soak in, maybe 10 minutes. Then apply the med, and let it soak-in. After 30 minutes or so, I will put a heavy, moisturizing cream on my feet (my hands are treated as I do this, too).
It is a cumbersome routine, but if I am consistent, it takes my feet to a level I can tolerate, ie. I can walk without wincing at every step.
At bedtime, I wrap my feet in Saran wrap, and pull on snug-fitting cotton socks. Usually this lets me fall asleep, but at some point, my feet are too warm, the itching returns, and the socks have to come off. Every once in awhile, I can make it through the night, and am so much the better for being able to keep my feet wrapped for several hours.