Methotrexate is a medication used to treat moderate to severe psoriasis. Here are some benefits and side effects based on the knowledge base:

Benefits
- Effectiveness: Methotrexate can calm down psoriasis and reduce body pain.
- Convenience: Typically taken once weekly, often in pill form, which can be done at home.
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Methotrexate is a medication used to treat moderate to severe psoriasis. Here are some benefits and side effects based on the knowledge base:

Benefits:
- Effectiveness: Methotrexate can calm down psoriasis and reduce body pain.
- Convenience: Typically taken once weekly, often in pill form, which can be done at home.
- Combination Use: Sometimes used with biologics for better results.

Side Effects:
- Common Side Effects: Fatigue, nausea, vomiting, diarrhea, headaches, mild hair loss.
- Serious Side Effects: Bone marrow suppression (low white blood cells, anemia, low platelets), kidney and liver dysfunction, increased risk of lymphoma, melanoma, and lung cancer.
- Long-term Use Risks: Accumulating toxicity, particularly liver disease.
- Supplementation: Often requires folic acid supplements to counteract depletion.

Special Considerations:
- Health Conditions: Not recommended for people with liver disease, low blood cell counts, or those who are pregnant or nursing.
- Monitoring: Routine blood tests for kidney and liver function are necessary.

For more detailed information, you can refer to the full article on MyPsoriasisTeam: [Methotrexate for Psoriasis](https://www.mypsoriasisteam.com/resources/metho...).

 This AI-generated response comes from MyPsoriasisTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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